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  • ANC = (total WBC) x (%segs + %bands)
  • Nadir usually occurs 5-10d after chemo
  • Duration of neutropenia depends on type of cancer treatment
    • Solid tumor treatments: <5d
    • Hematologic malignancies: 14d or longer
  • (Leukemia or lymphoma) + chemo most commonly associated with neutropenia

Neutropenic fever definition

  • ANC <500 OR <1000 with predicted nadir of <500 in 48h AND
  • Fever ≥ 38.3˚C (100.9˚F) once OR sustained temperature ≥38 (100.4) for >1hr
    • Oral temperature (do not obtain rectal temp)

See Also